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Natural Component of Apple Peels Found To Help Prevent Muscle Weakening

In search of an effective method to prevent muscle wasting that comes with illness and aging, researchers have located a natural compound that is very promising.

The findings reported in the June issue of Cell Metabolism (a Cell Press publication), identify a natural component of apple peels known as Ursolic Acid as a promising newnutritional therapy for the widespread and debilitating condition that affects nearly everyone at one time or another.

"Muscle wasting is a frequent companion of illness and aging," explained researchers from The University of Iowa, Iowa City. "It prolongs hospitalization, delays recoveries and in some cases prevents people going back home. It isn't well understood and there is no medicine for it."

The research team first looked at what happens to gene activity in muscles under conditions that promote weakening. Those studies turned up 63 genes that change in response to fasting in both people and mice and another 29 that shift their expression in the muscles of both people who are fasting and those with spinal cord injury. Comparison of those gene expression signatures to the signatures of cells treated with more than 1300 bio-active small molecules led them to ursolic acid as a compound with effects that might counteract those of atrophy.

"Ursolic Acid is an interesting natural compound," they said. "It's part of a normal diet as a component of apple peels. They always say that an apple a day keeps the doctor away..."

The researchers next gave Ursolic Acid to fasted laboratory subjects. Those experiments showed that ursolic acid could protect against muscle weakening as predicted. When ursolic acid was added to the food of normal subjects for a period of weeks, their muscles grew. Those effects were traced back to enhanced insulin signaling in muscle and to corrections in the gene signatures linked to atrophy.

The subjects given ursolic acid also became leaner and had lower blood levels of glucose, cholesterol and triglycerides. The findings therefore suggest that ursolic acid may be responsible for some of the overall benefits of healthy eating.

"We know if you eat a balanced diet like mom told us to eat you get this material," the researchers explained "People who eat junk food don't get this."

It is not yet clear whether the findings will translate to human patients, but the goal now is to "figure out if this can help people." If so, they don't yet know whether Ursolic Acid at levels that might be consumed as part of a normal diet might or might not be enough.

Lisa Beverly writes highly informative and researched articles for end consumers about a variety of health and fitness including remedies, weight loss, nutrition, slimming, weight loss products, bodybuilding supplements and diet tips. Article City






There are many conventional treatments for social anxiety disorder, however, many people may grow frustrated because these treatments. Most psychiatrists prescribe medications that can have powerful side effects with the hope that, apparently entirely to the person in question will have to take these drugs for the rest of their lives.

However, it is good to know that these drugs are not the only treatment for social anxiety disorder is available. In fact, there are ways that this disease can be defeated completely and effectively do away with what is, in fact, what most people are waiting for when they seek professional help.

When it comes to social anxiety disorder, this little-understood disease can wreak havoc on all in the lives of their victims. Many people suffer from social and professional as they find it unbearable to be out and among people because their body begins to react in a way your mind can not keep up. Most people just want to get rid of this disease.

When it comes to overcoming social anxiety, it is important to understand that this is a real illness and not something that is only in someone's head and that someone can simply wish away. That said, there are certain mental techniques that can be used to defeat the mechanism by which the functions of this disease.

The mind is a powerful tool and so is the focus of many treatments of social anxiety disorder. People are surprised to realize how effective visualization and positive thinking can be when done well and practiced to perfection. These techniques can be used to completely control these diseases.

It is important to know that at first, these treatments may seem like they are not working, because it can be hard to believe that a person's bodily functions can be influenced by your mind. However, that disbelief is but the first and most difficult obstacle to cross to learn to control the symptoms of this disorder in particular.

The key to mastering this disease is to understand that it stems from a fundamental imbalance and lack of a key element in the life of a person. This can be a physical lack, for example of a nutrient or essential vitamin, but in most cases, is simply a lack of a particular type of mental mechanism of coping.

After reading this article I hope they were able to get some ideas on how to overcome their social anxiety disorder.